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Molecular Cardiology Research Institute
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 Did you know . . .

 

- The MCRI is a world leader in molecular cardiology and cardiovascular research.

 

- MCRI investigators conduct molecular, cellular and translational research on blood vessels and vascular cells.

 

- MCRI investigators conduct molecular, cellular and translational research on the heart and cardiac cells.

 

- MCRI funding comes from the National Institutes of Health, many foundations, and private donations.



MCRI in the News

 

August 20, 2008 - In the Journal of the American College of Cardiology published today, Tufts Medical Center researchers, led by the MCRI's Dr. Richard Karas, report that the cholesterol-lowering drugs called statins neither cause cancer nor prevent it. 

 

May 1, 2008 - In a study published in the Proceedings of the National Academy of Sciences, MCRI researchers identify a new mechanism for high blood pressure.  The team, led by Dr. Michael Mendelsohn, found that blood vessel abnormalities, not just kidney abnormalities as has previously been believed, can cause high blood pressure.

 

February 1, 2008 - Richard Karas, MD, PhD is appointed as Vice Chairman of Scientific Affairs for the Department of Medicine

 

 

February 1, 2008 - Tufts Medical Center announced today that Michael E. Mendelsohn, MD will lead the organization’s research endeavors as Chief Scientific Officer

 

January 1, 2008 - MCRI Celebrates 10 Years of Ground-breaking Cardiovascular Research

 

MCRI Training and Staff Opportunities are available.

Recent MCRI Publications

 

Alsheikh-AA, Trikalinos T, Kent DM,  Karas RH.  Statins, low-density lipoprotein cholesterol and risk of cancer.  Journal of the American College of Cardiology 52(14):1141-1147, 2008. PubMed Abstract   Abstract 

 

Fernández AB, Karas RH, Alsheikh-Ali AA, Thompson PD.  Statins and interstitial lung disease: A systematic review of the literature and of FDA adverse event reports.  Chest 134(4):824-830.  PubMed Abstract

 

Davis BN, Hilyard AC, Lagna G, Hata A.  SMAD proteins control DROSHA-mediated microRNA maturation.  Nature 454(7200):56-61, 2008.  PubMed Abstract

 

Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ.  Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.  Circulation Research 102(11):1359-1367, 2008.  PubMed Abstract

 

Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.  High blood pressure arising from a defect in vascular function.  Proceedings of the National Academy of Sciences, USA 105(18):6702-6707, 2008.  PubMed Abstract

 

Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS.  The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with β-blockade.  Journal of Human Hypertension 22(7):512-515, 2008 Apr.  PubMed Abstract

 

Patten RD, Pourati I, Aronovitz MJ, Alsheikh-Ali A, Eder S, Force T, Mendelsohn ME, Karas RH.  17 β-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload.  Journal of Cardiac Failure 14(3):245-253, 2008.  PubMed Abstract

 

Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS.  Pharmacological Analysis of Human D1 and D2 Dopamine Receptor Missense Variants.  Journal of Molecular Neuroscience 34(3):211-223, 2008.  PebMed Abstract

 

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 118(1):259-271, 2008.  PubMed Abstract